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In chronic morphine-treated animals desensitization of OR was measured on ACase (Noble and Cox, 1996) and associated with tolerance to analgesic effects (Polastron et al., 1994)

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If you have a temporary deficiency or increased requirement (say, after a surgery or during recovery from an acute illness), you might only need a short course, perhaps a few weeks of injections, until your vitamin levels normalize or you can meet your needs by mouth again